N15 Beta-Amyloid (11-40), Rat, Uniformly Labeled
N15 uniformly labeled beta-amyloid peptide (A-beta). Beta-amyloid peptide (A-beta), the major constituent of amyloid plaques in the brains of Alzheimer’s patients, is thought to be the cause of Alzheimer’s Disease (AD). Alzheimer’s diseased brains show significant levels of A-beta (11-40) and A-beta (11-42) 1. The ß-secretase enzyme or ß-amyloid precursor protein-cleaving enzyme (BACE) generates the N terminus of Aß, producing full-length A-beta (1-40 and 1-42) and/or truncated A-beta (11-40 and 11-42) 1. The abundance of A-beta (11-40 and 11-42) produced by BACE suggests that they might be playing an important role in Alzheimer’s disease pathogenesis.
$850.00
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Product Details
- Size: 1.0 mg
- Physical State: White lyophilized powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Sequence:
E V R H Q K L V F F A E D V G S N K G A I I G L M V G G V V
- Source: Recombinant. A DNA sequence encoding the rat beta-amyloid (11-40) sequence was expressed in E. coli and uniformly labeled with N15 as the nitrogen source.
- Purity: >97% by Mass Spec.
- Molecular Mass: 3,209 Da theoretical
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References
1. Liu, K., et al., (2002) Biochemistry, 41 : 3128-36.
