Entacapone
Potent catechol O-methyltransferase (COMT) inhibitor (IC50 = 14.3, 20.1 and 73.3 nM for rat liver soluble COMT, total COMT and membrane-bound COMT respectively). Increases bioavailability of L-DOPA as adjunct therapy for Parkinson’s disease. Inhibits a- synuclein aggregation in vitro and inhibits a-synuclein-induced cell death in PC-12 cells. Antioxidant. Inhibits oxidative stress-induced cell death.
$76.00 – $209.00
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Product Details
- Physical State: Yellow Powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Molecular Mass: 305.3
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References
1. Forsberg, M., et al. J. Pharmacol. Exp. Ther. 2003 304:498
2. Merello, M., et al. J. Neurol. Neurosurg. Psychiatry. 1994 57:186
3. Di Giovanni, S., et al. J. Biol. Chem. 2010 285:14941
4. Chen, A.Y., et al. Med. Sci. Monit. 2016 22:687
