Niclosamide
Reversibly inhibits mTORC1 signaling and stimulates autophagy. Inhibits activation and nuclear translocation of STAT3 selectively over STAT1 and STAT5. Inhibits transcription of STAT3 target genes and induces cell cycle arrest and apoptosis in cells with constitutively active STAT3. Reverses radioresistance in human lung cancer cells and xenografts.
$57.00 – $162.00
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Product Details
- Physical State: Yellow Powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Molecular Mass: 327.1
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References
1. Balgi, A.D., et al., (2009) PloS One, 4 : e7124
2. Ren, X., et al., (2010) ACS Med. Chem. Lett., 1 : 454
3. Shuo, Y., et al., (2013) Mol. Cancer Ther., 13 : 606
