Ribavirin

Clinically useful antiviral guanosine nucleoside analog, active against RSV, hepatitis C and other RNA and DNA viruses. Binds to and redistributes eIF4E from the nucleus to the cytoplasm3 and inhibits eIF4E-dependent Akt survival signaling. Displays efficacy against atypical teratoid/rhabdoid tumors and inhibits glioma cell growth. A molecular docking study suggests effectiveness against SARS-CoV-2 RNA-dependent RNA polymerase.

Catalog ID: CV-1046

$67.00 – $162.00

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  • Product Details
    • Physical State: White powder
    • Temperature Storage: -20°C
    • Temperature Shipping: Ambient
    • Molecular Mass: 244.2

  • References

    1. Bougie, I., and Bisaillon, M., (2003) J. Biol. Chem., 278 : 52471
    2. Crotty, S., et al., (2000) Nat. Med., 6 : 1375
    3. Kentsis, A., et al., (2004) Proc. Natl. Acad. Sci. USA, 101 : 18105
    4. Tan, K., et al., (2008) Biochem. Biophys. Res. Commun., 375 : 341
    5. Casaos, J., et al., (2018) Oncotarget, 9 : 8054
    6. Volpin, F., et al., (2017) Oncogene, 36 : 3037
    7. Elfiky, A.A., (2020) Life Sci., 117592 (epub ahead of print)

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