Tolcapone

Catechol O-methyltransferase inhibitor (COMT), inhibiting both brain and peripheral enzymes 1. Potent inhibitor of alpha-synuclein and beta-amyloid oligomerization and fibrillogenesis protecting against extracellular toxicity 2. Binds to transthyretin (TTR) with high affinity (21 to 58 nM) and inhibits TTR aggregation in human plasma and prevents TTR-induced cytotoxicity in vitro. Stabilizes TTR in mice and humans in vivo 3. Inhibits O-methylation of exogenous polyphenols such as EGCG 4. Cell permeable. Orally bioavailable.

Catalog ID: N-3007

$95.00 – $380.00

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  • Product Details
    • Physical State: Yellow powder
    • Temperature Storage: -20°C
    • Temperature Shipping: Ambient
    • Molecular Mass: 273.2

  • References

    1. Mennini, T., et al., (1987) Naunyn-Schmied. Arch. Pharmacol., 336 : 478
    2. Kato, G., and Weitsch, A.F., (1988) Clin. Neuropharmacol., 11 : S43
    3. Plaisant, F., et al., (2003) Neuropharmacology, 44 : 801
    4. Seo, M.K., et al., (2016) Psychopharmacology (Berl.), 233 : 2617
    5. Slusarcyk, J., et al., (2017) J. Neurochem., 136 : 958

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