DAPT

Inhibitor of gamma-secretase (IC50 in human primary neurons = 115 nM for total amyloid beta or 200 nM for Amyloid Beta 42 specifically) ¹. Oral administration of DAPT has been shown to reduce levels of Amyloid Beta in brain extract, cerebrospinal fluid and plasma from mice and rats ^2,3. DAPT blocks Notch signaling which promotes neuronal differentiation of precursor cells ⁴. Enhances iPS cells without oncogenes KLF4 and CMYC ⁵. Cell permeable.