Zileuton

Reversible inhibitor of 5-Lipoxygenase (IC50 = 500 nM in RBL-1 cells and 300 nM rat PMNLs)1. It also inhibited leukotriene B4 biosynthesis (IC50’s = 400nM rat PMNL, 400nM human PMNL) 1. Zileuton suppressed prostaglandin biosynthesis via interference with arachidonic acid release in macrophages independent of 5-LO inhibition (IC50 = 13 μM PGE2 inhibition in LPS-stimulated whole blood) 2. Restores memory impairments and reverses amyloid and tau pathology in an Alzheimer’s mouse model 3.

Catalog ID: N-3023

$57.00 – $228.00

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  • Product Details
    • Physical State: White powder
    • Temperature Storage: -20°C
    • Temperature Shipping: Ambient
    • Molecular Mass: 236.3

  • References

    1. Waring, P., and Beaver, J., (1996)Gen. Pharmacol., 27 : 1311
    2. Fitzpatrick, L.M., et al., (2000) Dig. Dis. Sci., 45 : 2327
    3. Di Meco, A., et al., (2014) Neurobiol. Aging, 35 : 2458

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