TRO 19622
Neuroregenerative and neuroprotective agent acting at components of the mitochondrial permeability transition pore (MPTP) 1. Rescues motor neurons from axotomy-induced cell death and promotes nerve regeneration following sciatic nerve crush in mice. Reduces ROS and NLRP3 inflammasome activation in a mouse model of intracerebral hemorrhage 2. Inhibits MPTP opening and protects neurons from apoptosis 3. Induces oligodendrocyte maturation in culture and promotes myelin regeneration in vivo in a rodent model 4.
$105.00 – $380.00
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Product Details
- Physical State: White crystalline powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Molecular Mass: 399.7
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References
1. Bordet, T., et al., (2007) J. Pharmacol. Exp. Ther., 322 : 709
2. Ma, Q., et al., (2014) Ann. Neurol., 75 : 209
3. Martin, L.J., et al., (2011) J. Neurosci., 31 : 359
4. Magalon, K., et al., (2016) Neuropharmacology, 111 : 293
