Alpha-Synuclein, 96-140
Alpha-Synuclein (α-Synuclein) is a 14 kD (140 amino acids) acidic presynaptic protein and is a major component of Parkinson’s Disease (PD) aggregates. α-Synuclein is implicated in the pathogenesis of PD and related neurodegenerative disorders. α-Synuclein also accumulates in the brains of sporadic PD patients as a major component of Lewy bodies, which are intraneuronal cytoplasmic inclusions characteristic of PD. α-Synuclein appears to associate with other proteins that aggregate and is found in beta-amyloid plaques and neuritic tangles in Alzheimer’s disease 3. rPeptide offers a wide array of synuclein products, including fragments, mutants, preformed fibrils, and labeled versions in addition to the wild-type protein. A deletion mutant of α-synuclein (amino acids 96-140). Additional amino acid (Met) is attached at the N-terminus.
$425.00
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Product Details
- Size: 0.5 mg
- Physical State: White lyophilized powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Sequence:
MKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA
- Source: Recombinant. A DNA sequence encoding the human alpha-synuclein (96-140) sequence was expressed in E. coli. Additional amino acid (Met) is attached at the N-terminus.
- Purity: >95% by SDS-PAGE
- Molecular Mass: 5,217 Da theoretical
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References
1. Conway, K., et al., (2000) Biochemistry, 39 : 2552
2. Jakes, R., et al., (1994) FEBS Letters, 345 : 27
3. Masliah, E., et al., (2001) Proc. Natl. Acad. Sci., USA, 98 : 12245
4. Ueda, K., et al., (1993) Proc. Natl. Acad. Sci., USA, 90 : 11282
5. Grozdanov, V., et al., (2019) Ann Neurol, 86(4) : 593-606 -
Publications
J Am Soc Mass Spectrom.; doi: 10.1007/s13361-018-2002-2.
Cross-seeding of alpha-synuclein aggregation by amyloid fibrils of food proteins
Journal of Biological Chemistry; doi.org/10.1016/j.jbc.2021.100358
