Beta-Amyloid (1-40), TFA
Product background: Beta-Amyloid peptides (A-beta), the major constituent of amyloid plaques in the brains of Alzheimer’s patients, is thought to be a primary contributor of Alzheimer’s Disease (AD).
About the product: Expressed recombinantly in E. coli, Beta-Amyloid (1-40) is purified to our highest standards to ensure batch to batch consistency in both purity and quality.
Applications: The TFA (trifluoroacetic acid) counter ion of our Aβ ensures a highly monomeric starting material that could be suited to aggregation studies, seeding experiments, molecular standards, and more.
$200.00
-
Product Details
- Size: 1.0 mg
- Physical State: White lyophilized powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Sequence:
D A E F R H D S G Y E V H H Q K L V F F A E D V G S N K G A I I G L M V G G V V
- Source: Recombinant. A DNA sequence encoding the human beta-amyloid (1-40) sequence was expressed in E. coli
- Purity: >97% by Mass Spec.
- Molecular Mass: 4,329 Da theoretical
-
References
1. Yankner, B.A., et al., (1990) Science, 250 : 279-282
2. Stine, W.B., et al., (2003) J. Biol. Chem, 278 : 11612-11622
3. Frank, R.A., et al., (2003) Neurobiology of Aging, 24 : 521-536
4. Alsalahat, I., et al., (2021) Biochemistry and Biophysics Reports, 26 : 100943 -
Publications
Alzheimer’s Research & Therapy; doi.org/10.1186/s13195-020-00728-w.
Plasma metabolomics of presymptomatic PSEN1-H163Y mutation carriers: A pilot study.
bioRxiv; doi: doi.org/10.1101/2020.05.16.093559..
PLOS ONE; doi: 10.1371/journal.pone.0186636.
Biochim Biophys Acta Mol Basis Dis.; doi: 10.1016/j.bbadis.2016.11.020.
