H89
Protein kinase A inhibitor, IC50=135 nM. Also inhibits several other kinases, IC50 = 80, 120, 270, 2600 and 2800 nM for S6K1, MSK1, ROCKII, PKBα and MAPKAP-K1b, respectively. A useful probe for PKA but due to selectivity issues, H-89 should be used along with other PKA inhibitors to ascertain the role of PKA in cellular signaling pathways. Has been used in a novel assay employing in vivo substrate screening. Cell permeable.
$152.00
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Product Details
- Size: 5.0mg
- Physical State: Off-white powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Molecular Mass: 519.3
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References
1. Lochner, A., and Moolman, J.A., (2006) Cardiovasc. Drug. Rev., 24 : 261
2. Chijwa, T., et al., (1990) J. Biol. Chem., 265 : 5267
3. Hamaguchi, T., et al., (2015) Cell Struct. Funct., 40 : 1
