Triptolide
Possesses potent immunosuppressive and anti-inflammatory activity. Irreversibly inhibits eukaryotic transcription via covalent binding to XPB, a subunit of the transcription factor TFIIH1. Blocks transactivation of NFkB. Exhibits potent antiproliferative activity in 60 cancer cell lines (average IC50 = 12 nM) and synergizes with other anticancer agents. Inhibits the inflammatory response and remarkably decreases production of TNF-a, IL-1β and IL-6 in a rat model of rheumatoid arthritis.
$181.00
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Product Details
- Size: 5.0 mg
- Physical State: White powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Molecular Mass: 360.4
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References
1. He, Q.L., et al., (2015) Angew. Chem. Int. Ed. Eng., 54 : 1859
2. Lee, K.Y., et al., (1999) J. Biol. Chem., 274 : 13451
3. Qiao, Z., et al., (2016) Oncol. Lett., 11 : 3527
4. Fan, D., et al., (2016) Int. J. Mol. Sci., 17 : 498
