7-Cl-O-Nec1
A necrostatin-1 analog with superior potency, selectivity and metabolic stability at RIP1 inhibition (IC50 = 206 vs 494 nM). Displays greater efficacy at inhibition of necroptosis in Jurkat cells with no non-specific cytotoxicity (100 nM). Ameliorates disease progression in elastase-induced mouse abdominal aortic aneurysm model. Recommended for cellular and in vivo applications over necrostatin-15.
$352.00
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Product Details
- Size: 25.0 mg
- Physical State: Pale yellow to off-white powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Molecular Mass: 277.7
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References
1. Degterev, A., et al., (2005) Nat. Chem. Biol., 1 : 112
2. Teng, X., et al., (2005) Bioorg. Med. Chem. Lett., 15 : 5039
3. Nakahashi, N., et al., (2012) Cell Death Dis., 3 : e437
4. Wang, Q., et al., (2017) Sci. Rep., 7 : 42159
5. Degterev, A., et al., (2013) Nat. Chem. Biol., 9 : 192
