DTG
DTG is a high affinity agonist of the sigma (σ) receptor with roughly equal potency against both subtypes (σ1 and σ2 IC50’s ~ 30 nM). Induces heavy alcohol drinking in rats in a model of alcohol use disorder. Increases BDNF expression and attenuates ischemia/reperfusion-induced learning impairment in mouse models.
$57.00
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Product Details
- Size: 100 mg
- Physical State: White powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Molecular Mass: 239.32
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References
1. Weber, E., et al., (1986) Proc. Natl. Acad. Sci. USA, 83 : 8784
2. Scherz, M.W., et al., (1990) J. Med. Chem., 33 : 2421
3. Valenza, M., et al., (2020) Pharmacol. Biochem. Behav., 192 : 172914
4. Xu, Q., et al., (2015) Psychopharmacology (Berl), 232 : 1779
