BD1047 dihydrobromide

BD1047 is a potent and selective sigma-1 antagonist (IC50’s: σ1=0.93 nM, σ2=47 nM). It reduced convulsions, lethality, and locomotor activity induced by cocaine in mouse models. BD1047 attenuated high fat diet-induced peripheral neuropathy in mice. BD1047 displayed antinociceptive effects in several rodent pain models. It also inhibits the β-adrenergic receptor (IC50=145 nM).