Beta-Synuclein
Product background: Beta-Synuclein (β-Synuclein) is a presynaptic protein found to be a major component of Parkinson’s Disease (PD) aggregates and is implicated in the pathogenesis of PD and related neurodegenerative disorders.
About the product: Expressed recombinantly in E. coli, human Beta-Synuclein is purified to our highest standards to ensure batch to batch consistency in both purity and quality.
Applications: Beta-Synuclein is sold in 20mM Tris, 100mM NaCl, pH 7.4 to ensure a highly monomeric starting material that could be suited to aggregation studies, seeding experiments, molecular standards, and more.
$500.00
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Product Details
- Size: 1.0 mg
- Physical State: White lyophilized powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Sequence:
MDVFMKGLSM AKEGVVAAAE KTKQGVTEAA EKTKEGVLYV GSKTREGVVQ GVASVAEKTK EQASHLGGAV FSGAGNIAAA TGLVKREEFP TDLKPEEVAQ EAAEEPLIEP LMEPEGESYE DPPQEEYQEY EPEA
- Source: Recombinant. A DNA sequence encoding the human beta-synuclein sequence was expressed in E. coli.
- Purity: >95% by SDS-PAGE and Mass Spec.
- Molecular Mass: 14,288 Da theoretical
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References
1. Hashimoto, M., et al., (2001) Neuron, 32 : 213
2. Jakes, R., et al., (1994) FEBS Letters, 345 : 27 -
Publications
BioMedCentral; https://doi.org/10.1186/s13024-017-0187-7.
Resistance of naturally secreted -synuclein to proteolysis.
FEBS Journal; doi: 10.1096/fj.13-245852.
Elsevier B.V.; http://dx.doi.org/10.1016/j.febslet.2013.07.053 (Pay to view).
