Alpha-Syncuclein, Mouse
Product background: Alpha-Synuclein (α-Synuclein) is a presynaptic protein found to be a major component of Parkinson’s Disease (PD) aggregates and is implicated in the pathogenesis of PD and related neurodegenerative disorders.
About the product: Expressed recombinantly in E. coli, mouse Alpha-Synuclein is purified to our highest standards to ensure batch to batch consistency in both purity and quality.
Applications: The mouse Alpha-Synuclein is sold in 20mM Tris, 100mM NaCl, pH 7.4 to ensure a highly monomeric starting material that could be suited to aggregation studies, seeding experiments, molecular standards, and more.
$300.00 – $500.00
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Product Details
- Physical State: White lyophilized powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Sequence:
MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVTTVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGNIAAATGFVKKDQMGKGEEGYPQEGILEDMPVDPGSEAYEMPSEEGYQDYEPEA
- Source: Recombinant. A DNA sequence encoding the mouse alpha-synuclein, was expressed in E. coli.
- Purity: >95% by SDS-PAGE and Mass Spec.
- Molecular Mass: 14,485 Da theoretical
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References
1. Lashuel, H.A., et. al., (2002), J Mol Biol. 322 : 1089
2. Park, S.M., et. al., (2002) Blood, 100 : 2506
3. Polymeropoulos, M.H., et. al., (1997), Science, 276 : 2045 -
Publications
Alzheimers Dement.; doi: 10.1016/j.jalz.2019.02.002.
Histological Examination of Mitochondrial Morphology in a Parkinson’s Disease Model
J. Vis. Exp. (196), e65453, doi:10.3791/65453 (2023).