Alpha-Syncuclein, Mouse

Product background: Alpha-Synuclein (α-Synuclein) is a presynaptic protein found to be a major component of Parkinson’s Disease (PD) aggregates and is implicated in the pathogenesis of PD and related neurodegenerative disorders.

About the product: Expressed recombinantly in E. coli, mouse Alpha-Synuclein is purified to our highest standards to ensure batch to batch consistency in both purity and quality.

Applications: The mouse Alpha-Synuclein is sold in 20mM Tris, 100mM NaCl, pH 7.4 to ensure a highly monomeric starting material that could be suited to aggregation studies, seeding experiments, molecular standards, and more.

Catalog ID: S-1010

$300.00 – $500.00

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  • Product Details
    • Physical State: White lyophilized powder
    • Temperature Storage: -20°C
    • Temperature Shipping: Ambient
    • Sequence:
      MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVTTVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGNIAAATGFVKKDQMGKGEEGYPQEGILEDMPVDPGSEAYEMPSEEGYQDYEPEA
    • Source: Recombinant. A DNA sequence encoding the mouse alpha-synuclein, was expressed in E. coli.
    • Purity: >95% by SDS-PAGE and Mass Spec.
    • Molecular Mass: 14,485 Da theoretical

  • References

    1. Lashuel, H.A., et. al., (2002), J Mol Biol. 322 : 1089
    2. Park, S.M., et. al., (2002) Blood, 100 : 2506
    3. Polymeropoulos, M.H., et. al., (1997), Science, 276 : 2045

  • Publications

    Effects of single and combined immunotherapy approach targeting amyloid β protein and α-synuclein in a dementia with Lewy bodies-like model..

    Alzheimers Dement.; doi: 10.1016/j.jalz.2019.02.002.

    Markus Mandler, Edward Rockenstein, Cassia Overk, Michael Mante, Jazmin Florio, Anthony Adame, Changyoun Kim, Radmila Santic, Achim Schneeberger, Frank Mattner, Sabine Schmidhuber, Gergan Galabova, Brian Spencer, Eliezer Masliah, Robert A.Rissman

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