Alpha-Synuclein, 1-60

Product background: Alpha-Synuclein (α-Synuclein) is a presynaptic protein found to be a major component of Parkinson’s Disease (PD) aggregates and is implicated in the pathogenesis of PD and related neurodegenerative disorders.

About the product: Expressed recombinantly in E. coli, human Alpha-Synuclein 1-60 is purified to our highest standards to ensure batch-to-batch consistency in both purity and quality.

Applications: Human Alpha-Synuclein 1-60 is sold in 20mM Tris, 100mM NaCl, pH 7.4 to ensure a highly monomeric starting material that may be suited to aggregation studies, seeding experiments, molecular standards, and more.

Catalog ID: S-1011-1

$300.00

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  • Product Details
    • Size: 0.5 mg
    • Physical State: White lyophilized powder
    • Temperature Storage: -20°C
    • Temperature Shipping: Ambient
    • Sequence:
      MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYV GSKTKEGVVHGVATVAEKTK
    • Source: Recombinant. A DNA sequence encoding the human alpha-synuclein (1-60) sequence was expressed in E. coli.
    • Purity: >95% by SDS-PAGE
    • Molecular Mass: 6,149 Da theoretical

  • References

    1. Conway, K., et al., (2000) Biochemistry, 39 : 2552
    2. Jakes, R., et al., (1994) FEBS Letters, 345 : 27
    3. Masliah, E., et al., (2001) Proc. Natl. Acad. Sci., USA, 98 : 12245
    4. Ueda, K., et al., (1993) Proc. Natl. Acad. Sci., USA, 90 : 11282
    5. Grozdanov, V., et al., (2019) Ann Neurol, 86(4) : 593-606

  • Publications

    Native Top-Down Mass Spectrometry and Ion Mobility MS for Characterizing the Cobalt and Manganese Metal Binding of α-Synuclein Protein.

    J Am Soc Mass Spectrom.; doi: 10.1007/s13361-018-2002-2.

    Wongkongkathep, P., Han, J., Choi,T., Yin, S., Kim,H., Loo,J.

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