Alpha-Synuclein Preformed Fibrils
Product Background: Alpha-Synuclein (α-Synuclein) is a presynaptic protein found to be a major component of Parkinson’s Disease (PD) aggregates and is implicated in the pathogenesis of PD and related neurodegenerative disorders. These preformed fibrils of α-Synuclein may be used as a model for the pathogenic form of α-Synuclein in numerous neuropathies.
About the product: Expressed recombinantly in E. coli, human Alpha-Synuclein is purified to our highest standards to ensure batch-to-batch consistency in both purity and quality. The human Alpha-Synuclein is then made into preformed fibrils with their presence and length being confirmed by transmission electron microscopy (TEM) and thioflavin fluorescence assay.
Applications: These human Alpha-Synuclein fibrils are sold as a frozen 10mg/mL solution of total protein. The fibrils may be suitable for either in vitro or in vivo requirements such as fibril stability, seeding experiments, aggregation studies, or preformed fibril injections. Alpha-Synuclein preformed fibrils may also be used in the study of Parkinson’s Disease or Lewy Body Dementia.
$300.00 – $3,500.00
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Product Details
- Physical State: Liquid
- Temperature Storage: -80°C
- Temperature Shipping: Dry Ice
- Sequence:
MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA
- Source: Recombinant. A DNA sequence encoding the human alpha-synuclein (1-140) sequence was expressed in E. coli and was then made into preformed fibrils.
- Purity: >95% by SDS-PAGE
- Molecular Mass: N/A. See Estimated Size on Data Sheet
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References
1. Li, J., et al., (2004) Chemistry & Biology 11 (11) : 1513-1521
2. Okuzumi, A., et al., (2018) Acta Neuropathol Commun 6 : 96 -
Publications
Cell Biosci (2024) 14 (1), 26 DOI: 10.1186/s13578-024-01208-6
ACS Chem Neurosci (2023) 14 (21), 3905-3912 DOI: 10.1021/acschemneuro.3c00470
