Apicidin
Cyclopeptide inhibitor of histone deacetylases (HDACs). Inhibits HeLa cell proliferation (IC50=50-100 nM) and induces reversible transcriptional activation of p21 (WAF1). Decreases HIF1a protein levels and transcriptional activity in human and mouse tumor cell lines. Cell permeable.
$105.00 – $418.00
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Product Details
- Physical State: White powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Molecular Mass: 623.8
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References
1. Darkin-Rattray, S.J., et al., (1996) Proc. Natl. Acad. Sci. USA., 93 : 13143
2. Han, J.W., et al., (2000) Cancer Res., 60 : 6068
3. Kim, S.H., et al., (2007) Oncol. Rep., 17 : 647
