Beta-Amyloid (1-28)
Product background: Beta-Amyloid peptides (A-beta), the major constituent of amyloid plaques in the brains of Alzheimer’s patients, is thought to be a primary contributor to Alzheimer’s Disease (AD).
About the product: Beta-Amyloid (1-28) is produced as a synthetic peptide, rather than expressed in E. coli, and is purified to our highest standards to ensure batch-to-batch consistency in both purity and quality.
Applications: The TFA (trifluoroacetic acid) counter-ion ensures a highly monomeric starting material that may be suited to aggregation studies, seeding experiments, molecular standards and more.
$115.00 – $195.00
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Product Details
- Physical State: White lyophilized powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Sequence:
D A E F R H D S G Y E V H H Q K L V F F A E D V G S N K
- Source: Synthetic peptide
- Purity: >95%
- Molecular Mass: 3,262.5 Da
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References
1. Yankner, B., et al., (1990) Science, 250 : 279-282
2. Stine, W., et al., (2003) J. Biol. Chem, 278 : 11612-11622
3. Frank, R., et al., (2003) Neurobiology of Aging, 24 : 521-536
4. Gericke, C., et al., (2020) Front. Immunol., 11 : 1029 -
Publications
Springer; https://doi.org/10.1186/s40478-018-0626-x.
A Hairpin Motif in the Amyloid-β Peptide Is Important for Formation of Disease-Related Oligomers
Journal of the American Chemical Society (2023) 145 (33), 18340-18354 DOI: 10.1021/jacs.3c03980
