Beta-Amyloid (1-40), HFIP
Product background: Beta-Amyloid peptides (A-beta), the major constituent of amyloid plaques in the brains of Alzheimer’s patients, is thought to be a primary contributor of Alzheimer’s Disease (AD).
About the product: Expressed recombinantly in E. coli, Beta-Amyloid (1-40) is purified to our highest standards to ensure batch to batch consistency in both purity and quality. This product if treated with HFIP (hexofluoro-isopropanol) and then dried, leaving a clear dry film, rather than a lyophilized powder.
Applications: The HFIP counter ion of our Aβ ensures a highly monomeric starting material that could be suited to aggregation studies, seeding experiments, molecular standards, and more.
$250.00
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Product Details
- Size: 1.0 mg
- Physical State: Clear, dry film
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Sequence:
D A E F R H D S G Y E V H H Q K L V F F A E D V G S N K G A I I G L M V G G V V
- Source: Recombinant. A DNA sequence encoding the human beta-amyloid (1-40) sequence was expressed in E. coli
- Purity: >97% by Mass Spec.
- Molecular Mass: 4,329 Da theoretical
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References
1. Yankner, B.A., et al., (1990) Science, 250 : 279-282
2. Stine, W.B., et al., (2003) J. Biol. Chem, 278 : 11612-11622
3. Frank, R.A., et al., (2003) Neurobiology of Aging, 24 : 521-536
4. Mohamed, T., (2018) ACS Chem. Neurosci., 9, 4 : 773–782 -
Publications
Molecular and Cellular Neuroscience; https://doi.org/10.1016/j.mcn.2019.103390.
Soluble Aβ42 Acts as Allosteric Activator of the Core Cholinergic Enzyme Choline Acetyltransferase.
www.ncbi.nlm.nih.gov; doi: 10.3389/fnmol.2018.00327.
RSC Advances; DOI: 10.1039/C7RA02889J.
Brain; doi: 10.1093/brain/awv318..
NLRP3 Inflammasome Is Expressed and Functional in Mouse Brain Microglia but Not in Astrocytes.
PLOS ONE; DOI: 10.1371/journal.pone.0130624.
ACS Publications; DOI: 10.1021/bi5010409.
