Beta-Amyloid (1-40), NaOH
Product background: Beta-Amyloid peptides (A-beta), the major constituent of amyloid plaques in the brains of Alzheimer’s patients, is thought to be a primary contributor of Alzheimer’s Disease (AD).
About the product: Expressed recombinantly in E. coli, Beta-Amyloid (1-40) is purified to our highest standards to ensure batch to batch consistency in both purity and quality.
Applications: The NaOH counter ion of our Aβ is lyophilized in a basic environment, which some consider to be more physiologically relevant and less toxic. It also ensures a highly monomeric starting material that could be suited to aggregation studies, seeding experiments, molecular standards, and more.
$140.00
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Product Details
- Size: 0.5 mg
- Physical State: White lyophilized powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Sequence:
D A E F R H D S G Y E V H H Q K L V F F A E D V G S N K G A I I G L M V G G V V
- Source: Recombinant. A DNA sequence encoding the human beta-amyloid (1-40) sequence was expressed in E. coli
- Purity: >97% by Mass Spec.
- Molecular Mass: 4,329 Da theoretical
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References
1. Yankner, B.A., et al., (1990) Science, 250 : 279-282
2. Stine, W.B., et al., (2003) J. Biol. Chem, 278 : 11612-11622
3. Frank, R.A., et al., (2003) Neurobiology of Aging, 24 : 521-536
4. Benoit, S., (2020) Scientific Reports,11 : 6622 -
Publications
Effect of methionine-35 oxidation on the aggregation of amyloid-β peptide.
ScienceDirect; doi:10.1016/j.bbrep.2015.07.017.
Characterization of Novel Src Family Kinase Inhibitors to Attenuate Microgliosis.
PLOS ONE; DOI: 10.1371/journal.pone.0132604.
