Beta-Amyloid (1-40), Scrambled
Product background: Beta-Amyloid peptides (A-beta), the major constituent of amyloid plaques in the brains of Alzheimer’s patients, is thought to be a primary contributor of Alzheimer’s Disease (AD).
About the product: Expressed recombinantly in E. coli, Beta-Amyloid (1-40), Scrambled is purified to our highest standards to ensure batch to batch consistency in both purity and quality.
Applications: Aβ (1-40), Scrambled is a control peptide with a scrambled amino acid sequence which does not aggregate as native Beta-Amyloid. It is used as a negative control for aggregation assays.
$150.00 – $275.00
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Product Details
- Physical State: White lyophilized powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Sequence:
K V K G L I D G A H I G D L V Y E F M D S N S F R E G V G A G H V H V A Q V E F
- Source: Recombinant. A DNA sequence encoding the human beta-amyloid(1-40) scrambled sequence was expressed in E. coli
- Purity: >97% by Mass Spec.
- Molecular Mass: 4,329 Da theoretical
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References
1. Yankner, B.A., et al., (1990) Science, 250 : 279-282
2. Stine, W.B., et al., (2003) J. Biol. Chem, 278 : 11612-11622
3. Frank, R.A., et al., (2003) Neurobiology of Aging, 24 : 521-536
4. Alsalahat, I., et al., (2021) Biochemistry and Biophysics Reports, 26 : 100943
5. Hu, J., et al., (1998) Brain Research, 785 : 195-206 -
Publications
A Hairpin Motif in the Amyloid-β Peptide Is Important for Formation of Disease-Related Oligomers
Journal of the American Chemical Society (2023) 145 (33), 18340-18354 DOI: 10.1021/jacs.3c03980
