Beta Amyloid (1-42), Aggregation Kit
Product background: Beta-Amyloid peptides (A-beta), the major constituent of amyloid plaques in the brains of Alzheimer’s patients, is thought to be a primary contributor to Alzheimer’s Disease (AD).
About the product: Expressed recombinantly in E. coli, Beta-Amyloid (1-42) is purified to our highest standards to ensure batch-to-batch consistency in both purity and quality. In addition to the Beta-Amyloid (1-42) in NH4OH counter-ion, this kit includes reagents to initiate and detect aggregation through thioflavin fluorescence assay.
Applications: The Beta-Amyloid aggregation kit allows for time-based monitoring of the aggregation process through thioflavin fluorescence. Possible roles for this kit may include aggregation kinetics, aggregate stability, or therapeutic models.
$120.00 – $360.00
-
Product Details
- Physical State: White lyophilized powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Sequence:
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
- Source: Recombinant. A DNA sequence encoding the human beta-amyloid (1-42) sequence was expressed in E. coli
- Purity: >97% by Mass Spec.
- Molecular Mass: 4,514 Da theoretical
-
References
1. Yankner, B.A., et al., (1990) Science, 250 : 279-282
2. Stine, W.B., et al., (2003) J. Biol. Chem, 278 : 11612-11622
3. Frank, R.A., et al., (2003) Neurobiology of Aging, 24 : 521-536
4. Selkoe, D.J., (2001) Physiol. Rev, 81 : 741-766
5. Benoit, S., (2020) Scientific Reports, 11 : 6622 -
Publications
Marine bacterial extracts as a new rich source of drugs against Alzheimer’s disease.
Journal of Neurochemistry; https://doi.org/10.1111/jnc.14847.
Cell Death & Disease (2023) 14 (3), 192 DOI: 10.1038/s41419-023-05714-2
Mol Cell Proteomics (2023) 22 (5), 100542 DOI: 10.1016/j.mcpro.2023.100542
Super-resolution imaging unveils the self-replication of tau aggregates upon seeding
Cell Reports (2023) 42 (7), 112725 DOI: 10.1016/j.celrep.2023.112725
Geroscience (2023) 45 (2), 1095-1113 DOI: 10.1007/s11357-022-00708-y
The Amyloid Precursor Protein Modulates the Position and Length of the Axon Initial Segment
J Neurosci (2023) 43 (10), 1830-1844 DOI: 10.1523/JNEUROSCI.0172-22.2023
Alzheimer’s Dement. 2024; 20: 7805–7818. https://doi.org/10.1002/alz.14243
Functional BRI2-TREM2 interactions in microglia: implications for Alzheimer’s and related dementias
EMBO Rep (2024) 25 (3), 1326-1360 DOI: 10.1038/s44319-024-00077-x
Pharmacological Research, Volume 208, 2024, 107326, ISSN 1043-6618, https://doi.org/10.1016/j.phrs.2024.107326.
Cell Rep Med (2024) 5 (8), 101669 DOI: 10.1016/j.xcrm.2024.101669
