Beta Amyloid (1-42), Aggregation Kit
Beta-amyloid (A-beta) has been long reported as the major constituent of amyloid plaques in the brains of Alzheimer’s patients, and is believed by many to be the cause of Alzheimer’s Disease (AD). AD is the most common neurodegenerative disease and afflicts more than 10% of the population over 65. Recombinantly expressed and sourced from E. coli, rPeptide’s high quality beta-amyloid products offer batch-to-batch consistency and ultrapure starting material for your research needs. The beta-amyloid aggregation kit comes with the NH4OH counter-ion of the peptide, which is supplied as a stable monomer and can easily form aggregates in most experiments. Such methods can be used to study the kinetics, inhibition, and overall effects aggregation inhibiting compounds.
This kit allows researchers to monitor the properties of amyloid aggregation via Thioflavin T fluorescence assay, which also provides a way to test various compounds and methods of preventing aggregation.
$120.00 – $360.00
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Product Details
- Physical State: White lyophilized powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Sequence:
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
- Source: Recombinant. A DNA sequence encoding the human beta-amyloid (1-42) sequence was expressed in E. coli
- Purity: >97% by Mass Spec.
- Molecular Mass: 4,514 Da theoretical
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References
1. Yankner, B.A., et al., (1990) Science, 250 : 279-282
2. Stine, W.B., et al., (2003) J. Biol. Chem, 278 : 11612-11622
3. Frank, R.A., et al., (2003) Neurobiology of Aging, 24 : 521-536
4. Selkoe, D.J., (2001) Physiol. Rev, 81 : 741-766
5. Benoit, S., (2020) Scientific Reports, 11 : 6622 -
Publications
Marine bacterial extracts as a new rich source of drugs against Alzheimer’s disease.
Journal of Neurochemistry; https://doi.org/10.1111/jnc.14847.
Cell Death & Disease (2023) 14 (3), 192 DOI: 10.1038/s41419-023-05714-2
Mol Cell Proteomics (2023) 22 (5), 100542 DOI: 10.1016/j.mcpro.2023.100542
Super-resolution imaging unveils the self-replication of tau aggregates upon seeding
Cell Reports (2023) 42 (7), 112725 DOI: 10.1016/j.celrep.2023.112725
Geroscience (2023) 45 (2), 1095-1113 DOI: 10.1007/s11357-022-00708-y
The Amyloid Precursor Protein Modulates the Position and Length of the Axon Initial Segment
J Neurosci (2023) 43 (10), 1830-1844 DOI: 10.1523/JNEUROSCI.0172-22.2023
Alzheimer’s Dement. 2024; 20: 7805–7818. https://doi.org/10.1002/alz.14243
Functional BRI2-TREM2 interactions in microglia: implications for Alzheimer’s and related dementias
EMBO Rep (2024) 25 (3), 1326-1360 DOI: 10.1038/s44319-024-00077-x
Pharmacological Research, Volume 208, 2024, 107326, ISSN 1043-6618, https://doi.org/10.1016/j.phrs.2024.107326.
Cell Rep Med (2024) 5 (8), 101669 DOI: 10.1016/j.xcrm.2024.101669
