Beta-Amyloid (1-42), HCl
Product background: Beta-Amyloid peptides (A-beta), the major constituent of amyloid plaques in the brains of Alzheimer’s patients, is thought to be a primary contributor to Alzheimer’s Disease (AD).
About the product: Expressed recombinantly in E. coli, Beta-Amyloid (1-42) is purified to our highest standards to ensure batch-to-batch consistency in both purity and quality.
Applications: The HCl counter-ion is lyophilized in an acidic environment, which some consider to be more physiologically relevant and less toxic. It also ensures a highly monomeric starting material that may be suited to aggregation studies, seeding experiments, molecular standards and more.
$200.00 – $350.00
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Product Details
- Physical State: White lyophilized powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Sequence:
D A E F R H D S G Y E V H H Q K L V F F A E D V G S N K G A I I G L M V G G V V I A
- Source: Recombinant. A DNA sequence encoding the human beta-amyloid (1-42) sequence was expressed in E. coli
- Purity: >97% by Mass Spec.
- Molecular Mass: 4,514 Da theoretical
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References
1. Yankner, B.A., et al., (1990) Science, 250 : 279-282
2. Stine, W.B., et al., (2003) J. Biol. Chem, 278 : 11612-11622
3. Frank, R.A., et al., (2003) Neurobiology of Aging, 24 : 521-536
4. Ismail, T., Vancha, SR., & Kanapathipillai, M., (2018) Pept Sci.; 110 : e24093 -
Publications
Soluble Aβ42 Acts as Allosteric Activator of the Core Cholinergic Enzyme Choline Acetyltransferase.
www.ncbi.nlm.nih.gov; doi: 10.3389/fnmol.2018.00327.
Cell Reports (2023) 42 (10), 113240 DOI: 10.1016/j.celrep.2023.113240
