Beta-Amyloid (1-42), HFIP
Product background: Beta-Amyloid peptides (A-beta), the major constituent of amyloid plaques in the brains of Alzheimer’s patients, is thought to be a primary contributor of Alzheimer’s Disease (AD).
About the product: Expressed recombinantly in E. coli, Beta-Amyloid (1-42) is purified to our highest standards to ensure batch to batch consistency in both purity and quality. This product if treated with HFIP (hexofluoro-isopropanol) and then dried, leaving a clear dry film, rather than a lyophilized powder.
Applications: The HFIP counter ion of our Aβ ensures a highly monomeric starting material that could be suited to aggregation studies, seeding experiments, molecular standards, and more.
$200.00 – $350.00
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Product Details
- Physical State: Clear, dry film
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Sequence:
D A E F R H D S G Y E V H H Q K L V F F A E D V G S N K G A I I G L M V G G V V I A
- Source: Recombinant. A DNA sequence encoding the human beta-amyloid (1-42) sequence was expressed in E. coli
- Purity: >97% by Mass Spec.
- Molecular Mass: 4,514 Da theoretical
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References
1. Yankner, B., et al., (1990) Science, 250 : 279-282
2. Stine, W., et al., (2003) J. Biol. Chem, 278 : 11612-11622
3. Frank, R., et al., (2003) Neurobiology of Aging, 24 : 521-536
4. Novo, M., Freire, S. & Al-Soufi, W., (2018) Sci Rep 8 : 1783 -
Publications
Development of an α-synuclein positron emission tomography tracer for imaging synucleinopathies
Cell (2023) 186 (16), 3350-3367.e19 DOI: 10.1016/j.cell.2023.06.004
Acta Neuropathologica Communications (2023) 11 (1), 135 DOI: 10.1186/s40478-023-01633-7
Simple, Reliable Protocol for High-Yield Solubilization of Seedless Amyloid-β Monomer
ACS Chem Neurosci (2023) 14 (1), 53-71 DOI: 10.1021/acschemneuro.2c00411
Frontiers in Aging Neurosciences (2023) 15, 1239140 DOI: 10.3389/fnagi.2023.1239140
Stress-mediated aggregation of disease-associated proteins in amyloid bodies
Sci Rep (2023) 13 (1), 14471 DOI: 10.1038/s41598-023-41712-2
Cerebral Cortex, Volume 33, Issue 4, 15 February 2023, Pages 1263–1276, https://doi.org/10.1093/cercor/bhac134
J Neuroinflammation (2024) 21 (1), 238 DOI: 10.1186/s12974-024-03238-w
J Neuroinflammation (2024) 21 (1), 273 DOI: 10.1186/s12974-024-03253-x
Structure (2024) 32 (5), 585-593.e3 DOI: 10.1016/j.str.2024.02.010
CNS Neurosci Ther (2024) 30 (4), e14511 DOI: 10.1111/cns.14511
Int J Mol Sci (2024) 25 (13) DOI: 10.3390/ijms25137316
Int J Mol Sci (2024) 25 (17) DOI: 10.3390/ijms25179626
