Beta-Amyloid (1-42), NaOH

Product background: Beta-Amyloid peptides (A-beta), the major constituent of amyloid plaques in the brains of Alzheimer’s patients, is thought to be a primary contributor of Alzheimer’s Disease (AD).

About the product: Expressed recombinantly in E. coli, Beta-Amyloid (1-42) is purified to our highest standards to ensure batch to batch consistency in both purity and quality.

Applications: The NaOH counter ion of our Aβ is lyophilized in a basic environment, which some consider to be more physiologically relevant and less toxic. It also ensures a highly monomeric starting material that could be suited to aggregation studies, seeding experiments, molecular standards, and more.

Catalog ID: A-1165

$200.00$350.00

  • Product Details

    • Physical State: White lyophilized powder
    • Temperature Storage: -20°C
    • Temperature Shipping: Ambient
    • Sequence:
      D A E F R H D S G Y E V H H Q K L V F F A E D V G S N K G A I I G L M V G G V V I A
    • Source: Recombinant. A DNA sequence encoding the human beta-amyloid (1-42) sequence was expressed in E. coli
    • Purity: >97% by Mass Spec.
    • Molecular Mass: 4,514 Da theoretical
  • References

    1. Yankner, B., et al., (1990) Science, 250 : 279-282
    2. Stine, W., et al., (2003) J. Biol. Chem, 278 : 11612-11622
    3. Frank, R., et al., (2003) Neurobiology of Aging, 24 : 521-536
    4. Novo, M., Freire, S. & Al-Soufi, W., (2018) Sci Rep 8 : 1783