Beta-Amyloid (1-42), NaOH
Product background: Beta-Amyloid peptides (A-beta), the major constituent of amyloid plaques in the brains of Alzheimer’s patients, is thought to be a primary contributor of Alzheimer’s Disease (AD).
About the product: Expressed recombinantly in E. coli, Beta-Amyloid (1-42) is purified to our highest standards to ensure batch to batch consistency in both purity and quality.
Applications: The NaOH counter ion of our Aβ is lyophilized in a basic environment, which some consider to be more physiologically relevant and less toxic. It also ensures a highly monomeric starting material that could be suited to aggregation studies, seeding experiments, molecular standards, and more.
$200.00 – $350.00
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Product Details
- Physical State: White lyophilized powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Sequence:
D A E F R H D S G Y E V H H Q K L V F F A E D V G S N K G A I I G L M V G G V V I A
- Source: Recombinant. A DNA sequence encoding the human beta-amyloid (1-42) sequence was expressed in E. coli
- Purity: >97% by Mass Spec.
- Molecular Mass: 4,514 Da theoretical
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References
1. Yankner, B., et al., (1990) Science, 250 : 279-282
2. Stine, W., et al., (2003) J. Biol. Chem, 278 : 11612-11622
3. Frank, R., et al., (2003) Neurobiology of Aging, 24 : 521-536
4. Novo, M., Freire, S. & Al-Soufi, W., (2018) Sci Rep 8 : 1783 -
Publications
Specific Binding of Alzheimer’s Aβ Peptides to Extracellular Vesicles
Int J Mol Sci (2024) 25 (7) DOI: 10.3390/ijms25073703
