Beta-Amyloid (1-42), Scrambled
Product background: Beta-Amyloid peptides (A-beta), the major constituent of amyloid plaques in the brains of Alzheimer’s patients, is thought to be a primary contributor of Alzheimer’s Disease (AD).
About the product: Expressed recombinantly in E. coli, Beta-Amyloid (1-42), Scrambled is purified to our highest standards to ensure batch to batch consistency in both purity and quality.
Applications: Aβ (1-42), Scrambled is a control peptide with a scrambled amino acid sequence which does not aggregate as native Beta-Amyloid. It is used as a negative control for aggregation assays.
$220.00 – $350.00
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Product Details
- Physical State: White lyophilized powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Sequence:
K V K G L I D G A H I G D L V Y E F M D S N S A I F R E G V G A G H V H V A Q V E F
- Source: Recombinant. A DNA sequence encoding the human beta-amyloid(1-42) scrambled sequence was expressed in E. coli
- Purity: >97% by Mass Spec.
- Molecular Mass: 4,514 Da theoretical
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References
1. Yankner, B,A., et al., (1990) Science, 250 : 279-282
2. Stine, W.B., et al., (2003) J. Biol. Chem, 278 : 11612-11622
3. Frank, R.A., et al., (2003) Neurobiology of Aging, 24 : 521-536
4. Alsalahat, I., et al., (2021) Biochemistry and Biophysics Reports, 26 : 100943
5. Hu, J., et al., (1998) Brain Research, 785 : 195-206 -
Publications
Alzheimer’s & Dementia; doi: 10.1002/trc2.12029.
Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity
Molecular Neurodegeneration (2023) 18 (1), 61 DOI: 10.1186/s13024-023-00654-z
Alzheimer’s Research and Therapy (2023) 15 (1), 174 DOI: 10.1186/s13195-023-01316-4
Cell Reports (2023) 42 (10), 113240 DOI: 10.1016/j.celrep.2023.113240
Alzheimer’s Dement. 2024; 20: 5940–5960. https://doi.org/10.1002/alz.14044
J Neuroinflammation (2024) 21 (1), 238 DOI: 10.1186/s12974-024-03238-w
EMBO Rep (2024) 25 (3), 1233-1255 DOI: 10.1038/s44319-024-00090-0
