Beta-Synuclein

Product background: Beta-Synuclein (β-Synuclein) is a presynaptic protein found to be a major component of Parkinson’s Disease (PD) aggregates and is implicated in the pathogenesis of PD and related neurodegenerative disorders.

About the product: Expressed recombinantly in E. coli, human Beta-Synuclein is purified to our highest standards to ensure batch to batch consistency in both purity and quality.

Applications: Beta-Synuclein is sold in 20mM Tris, 100mM NaCl, pH 7.4 to ensure a highly monomeric starting material that could be suited to aggregation studies, seeding experiments, molecular standards, and more.

Catalog ID: S-1003

$300.00 – $500.00

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  • Product Details
    • Physical State: White lyophilized powder
    • Temperature Storage: -20°C
    • Temperature Shipping: Ambient
    • Sequence:
      MDVFMKGLSM AKEGVVAAAE KTKQGVTEAA EKTKEGVLYV GSKTREGVVQ GVASVAEKTK EQASHLGGAV FSGAGNIAAA TGLVKREEFP TDLKPEEVAQ EAAEEPLIEP LMEPEGESYE DPPQEEYQEY EPEA
    • Source: Recombinant. A DNA sequence encoding the human beta-synuclein sequence was expressed in E. coli.
    • Purity: >95% by SDS-PAGE and Mass Spec.
    • Molecular Mass: 14,288 Da theoretical

  • References

    1. Hashimoto, M., et al., (2001) Neuron, 32 : 213
    2. Jakes, R., et al., (1994) FEBS Letters, 345 : 27

  • Publications

    Relationship of serum beta-synuclein with blood biomarkers and brain atrophy

    Alzheimers & Dementia (2023) 19 (4), 1358-1371 DOI: 10.1002/alz.12790

    Oeckl, Anderl-Straub, Danek et al

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