Bexarotene
A highly potent and selective retinoid X receptor (RXR) agonist (EC50=28, 25, 20 nM for RXRalpha, beta, gamma respectively) 1. Clinically useful antineoplastic agent for cutaneous T-cell lymphoma 2. Causes complete regression of mammary carcinoma 3. Bexarotene significantly increases clearance of soluble B-amyloid in a mouse Alzheimer′s model and increases cognitive ability 4. Reverses apoE4-driven brain pathology and behavioral deficitsin vivo 5.
$133.00 – $266.00
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Product Details
- Physical State: White powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Molecular Mass: 348.5
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References
1. Boehm, M.F., et al., (1995) J. Med. Chem., 38: 3146
2. Gniadecki, R., et al., (2007) Br. J. Dermatol., 157 : 433
3. Bischoff, E.D., et al., (1998) Cancer Res., 58 : 479
4. Cramer, P.E., et al., (2012) Science, 335 : 1503
5. Boehm-Cagan, A., and Michaelson, D.M., (2014) J. Neurosci., 34 : 7293
