C13, N15 Beta-Amyloid (1-40), Uniformly Labeled
Product background: Beta-Amyloid peptides (A-beta), the major constituent of amyloid plaques in the brains of Alzheimer’s patients, is thought to be a primary contributor to Alzheimer’s Disease (AD).
About the product: Expressed recombinantly and double isotope labeled in E. coli, human Beta-Amyloid (1-40) is purified to our highest standards to ensure batch-to-batch consistency in both purity and quality.
Applications: C13 and N15 double labeled Beta-Amyloid (1-40) is sold in HFIP counter-ion to ensure a highly monomeric starting material that may be used for NMR structural studies, as a molecular weight standard, a biomarker, and more.
$1,460.00 – $2,420.00
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Product Details
- Physical State: Clear, dry film
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Sequence:
D A E F R H D S G Y E V H H Q K L V F F A E D V G S N K G A I I G L M V G G V V
- Source: Recombinant. A DNA sequence encoding the human beta-amyloid (1-40) sequence was expressed in E. coli and uniformly labeled with C13 as the carbon source and N15 as the nitrogen source.
- Purity: >97% by Mass Spec.
- Molecular Mass: 4,576 Da theoretical
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References
1. Yankner, B., et al., (1990) Science, 250 : 279-282
2. Selkoe, D.J., (2001) Physiol. Rev, 81 : 741-766
3. Stine, W., et al., (2003) J. Biol. Chem, 278 : 11612-11622
4. Frank, R., et al., (2003) Neurobiology of Aging, 24 : 521-536
