C13, N15 Beta-Amyloid (1-43), Uniformly Labeled
N15 uniformly labeled beta-amyloid peptide (A-beta). A-beta is the major constituent of amyloid plaques in the brains of Alzheimer’s patients, and is thought to be the cause of Alzheimer’s Disease (AD). AD is the most common neurodegenerative disease and afflicts about 10% of the population over 60.
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Product Details
- Physical State: White lyophilized powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Sequence:
D A E F R H D S G Y E V H H Q K L V F F A E D V G S N K G A I I G L M V G G V V I A T
- Source: Recombinant. A DNA sequence encoding the human beta-amyloid (1-43) sequence was expressed in E. coli and uniformly labeled with C13 as the carbon source and N15 as the nitrogen source.
- Purity: >97% by Mass Spec.
- Molecular Mass: 4,878 Da theoretical
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References
1. Yankner, B., et al., (1990) Science, 250 : 279-282
2. Selkoe, D.J., (2001) Physiol. Rev, 81 : 741-766
3. Stine, W., et al., (2003) J. Biol. Chem, 278 : 11612-11622
4. Frank, R., et al., (2003) Neurobiology of Aging, 24 : 521-536
