C16
Inhibits RNA-dependent protein kinase (PKR, IC50 = 210 nM) 1. Inhibits ER stress-induced neuronal damage 2. Reduces brain PKR activation in vivo 3. Prevents apoptosis and IL-1 Beta production in an acute excitotoxic and neuroinflammatory rat model 4. Prevents Beta-amyloid peptide-induced inflammation in primary murine mixed co-cultures 5. Cell permeable.
$114.00 – $456.00
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Product Details
- Physical State: Orange powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Molecular Mass: 268.3
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References
1. Jammi, N.V., et al., (2003) Biochem. Biophys. Res. Commun., 308 : 50
2. Shimazawa, M., et al., (2006) Neurosci. Lett., 409 : 192
3. Ingrand, S., et al., (2007) FEBS Lett., 581 : 4473
4. Tronel, C., et al., (2014) Neurochem. Int., 64 : 73
5. Couturier, J., et al., (2011) J. Neuroinflammation, 8 : 72
