Camostat mesylate
A serine protease inhibitor inhibiting plasmin, kallikrein, thrombin as well as trypsin, which attenuates pancreatic fibrosis. Reduces weight gain and improves metabol-ism in obese rodent models. In clinical use (in Japan) for pancreatitis. Inhibits influenza virus replication in human tracheal epithelial cells. Reduces infection of Calu-3 lung cells by SARS-CoV-2 (responsible for COVID-19) via inhibition of the serine protease TMPRSS2 required for viral spike protein priming.
$238.00
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Product Details
- Size: 50.0mg
- Physical State: Off-white powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Molecular Mass: 494.5
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References
1. Gibo, J., et al., (2005) Lab. Invest., 85 : 75
2. Albarazanji, K., et al., (2019) Am. J. Physiol. Gastrointest. Liver Physiol., 316 : G653
3. Ueda, M., et al., (2015) Nephron, 129 : 223
4. Yamaya, M., et al., (2015) Pulm. Pharmacol. Ther., 33 : 66
5. Hoffmann, M., et al., (2020) Cell, 181 : 1
