Chloroquine Phosphate

Antimalarial drug. Inhibits autophagy in a variety of cell lines. Induces cell death in breast cancer cell lines and displays antitumor and antimetastatic activity in mouse models of breast cancer. Eliminates cancer stem cells via deregulation of Jak2 and DN/sup>1^{. Displays synergy when combined with the Raf inhibitor, vemurafenib, in brain tumors. Cell permeable and active in vivo.}