FITC Alpha-Synuclein
Product background: Alpha-Synuclein (α-Synuclein) is a presynaptic protein found to be a major component of Parkinson’s Disease (PD) aggregates and is implicated in the pathogenesis of PD and related neurodegenerative disorders.
About the product: Expressed recombinantly in E. coli, human Alpha-Synuclein is covalently labeled with FITC at the side chain of lysine residues and purified to our highest standards to ensure batch to batch consistency in both purity and quality.
Applications: The Alpha-Synuclein FITC is sold in 20mM Tris, 100mM NaCl, pH 7.4 to ensure a highly monomeric starting material that could be suited to aggregation studies, binding kinetics, immunofluorescence and more.
$550.00
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Product Details
- Size: 0.5 mg
- Physical State: White lyophilized powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Sequence:
MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA
- Source: Recombinant. A DNA sequence encoding the human alpha-synuclein (1-140) sequence was expressed in E. coli and had FITC molecules attached for fluorescence.
- Purity: >95% by SDS-PAGE and Mass Spec.
- Molecular Mass: Approximately 17kD
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References
1. Roberti, M., et al., (2007) Nat Methods 4 : 345–351
2. Dusa, A., et al. (2006) Biochemistry 45, 8 : 2752-2760
3. Van Rooijen., B.D. (2009) Journal of Molecular Biology 394, 5, 18 : 826-833
