FITC Tau-441
Product background: The Tau proteins are a family of neuronal microtubule associated proteins that are found in the neurofibrillary tangles often associated with Alzheimer’s Disease. Tau promotes the assembly and maintains the structure of microtubules in neuronal cells.
About the product: Tau-441 is the mature human Tau isoform with 441 amino acids and a mass of 46kDa. Expressed recombinantly in E. coli, Tau-441 is purified to our highest standards to ensure batch to batch consistency in both purity and quality. rPeptide’s human Tau-441 has been covalently labeled with Fluorescein Isothiocyanate on the side chain of lysine residues.
Applications: This FITC labeled form of Tau-441 is ideally suited to localization experiments, aggregation monitoring and other fluorescence-based studies without the need for mutations or further labeling.
$550.00 – $800.00
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Product Details
- Physical State: Lyophilized powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Sequence:
MAEPRQEFEV MEDHAGTYGL GDRKDQGGYT MHQDQEGDTD AGLKESPLQT PTEDGSEEPG SETSDAKSTP TAEDVTAPLV DEGAPGKQAA AQPHTEIPEG TTAEEAGIGD TPSLEDEAAG HVTQARMVSK SKDGTGSDDK KAKGADGKTK IATPRGAAPP GQKGQANATR IPAKTPPAPK TPPSSGEPPK SGDRSGYSSP GSPGTPGSRS RTPSLPTPPT REPKKVAVVR TPPKSPSSAK SRLQTAPVPM PDLKNVKSKI GSTENLKHQP GGGKVQIINK KLDLSNVQSK CGSKDNIKHV PGGGSVQIVY KPVDLSKVTS KCGSLGNIHH KPGGGQVEVK SEKLDFKDRV QSKIGSLDNI THVPGGGNKK IETHKLTFRE NAKAKTDHGA EIVYKSPVVS GDTSPRHLSN VSSTGSIDMV DSPQLATLAD EVSASLAKQG L
- Source: Recombinant. A DNA sequence encoding the human tau-441 (2N4R isoform) sequence was expressed in E. coli and had FITC molecules attached forfluorescence. No his-tag.
- Purity: >90% by SDS-PAGE
- Molecular Mass: Approximately 46kD to 50kDa
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References
1. von Bergen, M., Li, L., & Mandelkow, E., (2015) Methods Mol Biol., 299 : 175-84
2. Radli, M., et al., (2017) bioRxiv 211904 -
Publications
Nature Communications (2023) 14 (1), 5197 DOI: 10.1038/s41467-023-40927-1
An astrocyte BMAL1-BAG3 axis protects against alpha-synuclein and tau pathology
Neuron (2023) 111 (15), 2383-2398.e7 DOI: 10.1016/j.neuron.2023.05.006
Mol Neurobiol (2024). https://doi.org/10.1007/s12035-024-04295-1
