Gamma-Synuclein
Product background: Gamma-Synuclein (γ-Synuclein) is a presynaptic protein found to be a major component of Parkinson’s Disease (PD) aggregates and is implicated in the pathogenesis of PD and related neurodegenerative disorders.
About the product: Expressed recombinantly in E. coli, human Gamma-Synuclein is purified to our highest standards to ensure batch to batch consistency in both purity and quality.
Applications: The Gamma-Synuclein is sold in 20mM Tris, 100mM NaCl, pH 7.4 to ensure a highly monomeric starting material that could be suited to aggregation studies, seeding experiments, molecular standards, and more.
$300.00 – $500.00
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Product Details
- Physical State: White lyophilized powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Sequence:
MDVFKKGFSIAKEGVVGAVEKTKQGVTEAAEKTKEGVMYVGAKTKENVVQSVTSVAEKTKEQANAVSEAVVSSVNTVATKTVEEAENIAVTSGVVRKEDLRPSAPQQEGEASKEKEEVAEEAQSGGD
- Source: Recombinant. A DNA sequence encoding the human gamma-synuclein sequence was expressed in E. coli.
- Purity: >95% by SDS-PAGE and Mass Spec.
- Molecular Mass: 13,300 Da theoretical
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References
1. Pan, Z., et al., (2002) J. Biol. Chem. 277 : 35050
2. Bruening, W., et al., (2000) Cancer 88 : 2154
3. Ji, H., et al., (1997) Cancer Res. 57 : 759 -
Publications
Molecular Neurodegeneration; https://doi.org/10.1186/s13024-017-0187-7.
Molecular Neurobiology; doi: 10.1007/s12035-018-1313-4.
