IOS-1
Antagonist of macrophage migration inhibitory factor (MIF, a pro-inflammatory cytokine). Displays anti-inflammatory activity. Increases survival in severe sepsis 1. Inhibits airway remodeling in mouse asthma model 2. Blocks MIF-induced autophagy 3. Inhibits experimental autoimmune diabetes in a mouse model, reducing islet antigen-specific proliferative responses and adhesive cell-cell interactions 4. Active in cellular and mouse models. Reverses Amyloid Beta-induced toxicity in mouse and human neuronal cell lines 5.
$200.00 – $798.00
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Product Details
- Physical State: Off-white powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Molecular Mass: 235.2
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References
1.Al-Abed, Y., et al., (2005) J. Biol. Chem., 280 : 36541
2.Chen, P.F., et al., (2010) Mol. Med., 16 : 400
3.Chuang, Y.C., et al., (2012) PLoS One, 7 : e37613
4.Cvetkovic, I., et al., (2005) Endocrinology, 146 : 2942
5.Bacher, M., et al., (2010) Mol. Med., 16 : 116
