ISRIB
Integrated stress response inhibitor. Potently reverses the effects of initiation factor 2α (eIF2α) phosphorylation, IC50=5 nM 1. Enhances spatial and fear-associated learning in mice and enhances cognitive function 1,2. Mechanism of action involves activation of eiF2β 3. Suppresses ER stress-induced inflammatory gene expression 4. Potently attenuates amyloid β-induced neuronal cell death (12.5-25 nM) with no effect on amyloid β production 5. Reverses hippocampal-dependent cognitive deficits induced by traumatic brain injury in two different injury mouse models 6.
$114.00 – $456.00
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Product Details
- Physical State: White Powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Molecular Mass: 451.3
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References
1. Sidrauski, C., et al., (2013) Elife, 2 : e00498
2. Sekine, Y., et al., (2015) Science, 348 : 1027
3. Sidrauski, C., et al., (2015) Elife, 4 : e07314
4. Guthrie, L.N., et al., (2015) J. Biol. Chem., 291 : 15830
5. Hosoi, T., et al., (2016) J. Pharmacol. Sci., 131 : 292
6. Chou, A., et al., (2017) Proc. Natl. Acad. Sci., USA, 114 : E6420
