IU1
Selective inhibitor of Usp14 (IC50<4 µM). Enhances proteasome activity and substrate proteolysis 1,2. Inhibits Dengue virus replication 3. In prion-infected CAD5 cells activation of the ubiquitin proteasome system by IU1 is sufficient to induce clearance of polyubiquitinated substrates and reduce misfolded prion protein load 4. Attenuates ischemia/reperfusion-induced neuronal injury in a mouse model 5. Cell permeable.
$95.00 – $380.00
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Product Details
- Physical State: Beige powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Molecular Mass: 300.4
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References
1. Lee, B.H., et al., (2010) Nature, 467 : 1179
2. Lee, M.J., et al., (2010) Mol. Cell. Proteomics, 10 : R110
3. Nag, D.K., and Finley, D., (2012) Virus Res., 165 : 103
4. McKinnon, C., et al., (2016) Acta Neuropathol., 131 : 411
5. Min, J.W., et al., (2017) J. Neurochem., 140 : 826
