LM11A-31 2HCI

A nonpeptide neurotrophic factor receptor p75 (p75NTR) agonist which promotes survival signaling in neurotrophin-responsive cells 1. Promotes functional recovery in a mouse model of spinal contusion injury 2. Protects neurogenesis after traumatic brain injury 3. Reverses cholinergic neurite dystrophy in Alzheimer’s disease mouse models 4. Stabilizes neuronal calcium, preserves mitochondrial movement and protects against HIV-associated neuropathogenesis 5. Orally active and blood-brain barrier permeant.

Catalog ID: N-3005

$91.00 – $365.00

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  • Product Details
    • Physical State: Pale Yellow Powder
    • Temperature Storage: -20°C
    • Temperature Shipping: Ambient
    • Molecular Mass: 316.3

  • References

    1. Massa, S.M., et al., (2006) J. Neurosci., 26 : 5288
    2. Tep, C., et al., (2013) J. Neurosci., 33 : 397
    3. Shi, J., et al., (2013) Stem Cells, 31 : 2561
    4. Simmons, D.A., et al., (2014) PLoS One, 9(8) : e102136
    5. Meeker, R.B., et al., (2016) Exp. Neurol., 275 Pt1 : 182

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