LM22A-4

Small molecule BDNF mimetic displaying neurotrophic activity. Partial agonist at TrkB and activates TrkB signaling. In in vitro models of neurodegenerative disease, it prevented neuronal degeneration with equal efficacy to that of BDNF. After in vivo administration, it caused hippocampal and striatal TrkB activation in mice and improved motor learning after traumatic brain injury in rats ¹. Improves respiratory function in a mouse model of Rett syndrome ².