MLN4924 (Pevonedistat)
Potent and selective NEDD8-activating enzyme (NAE) inhibitor. It disrupts cullin-RING ligase-mediated protein turnover leading to apoptosis in human tumor cells. Suppresses the growth of human tumor xenografts in mice. Upregulates PD-L1 expression and enhances the efficacy of immune checkpoint blockade in glioblastoma. Modulates tumor microenvironment. Cell permeable
$171.00 – $627.00
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Product Details
- Physical State: White powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Molecular Mass: 443.2
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References
1. Soucy, T.A., et al., (2009) Nature, 458 : 732
2. Milhollen, M.A., et al., (2010) Blood, 116 : 1515
3. Zhou, S., et al., (2019) Int. J. Cancer, 145 : 763
4. Zhou, L., et al., (2019) Mol. Cancer, 18 : 77
