N15 APP 669-711, Uniformly Labeled
Product background: Amyloid Precursor Protein (APP) is a membrane spanning protein that functions as the precursor to Amyloid-Beta in plaques of Alzheimer’s Disease patients. The extra cellular region is proteolytically cleaved to release amyloid peptides.
About the product: Expressed recombinantly and isotope labeled in E. coli, N15 APP 669-711 is purified to our highest standards to ensure batch-to-batch consistency in both purity and quality.
Applications: N15 labeled APP 669-711 is sold in HFIP counter-ion to ensure a highly monomeric starting material that may be used for NMR structural studies, as a molecular weight standard, a biomarker, and more.
$800.00 – $1,500.00
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Product Details
- Physical State: White lyophilized powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Source: Recombinant. A DNA sequence encoding the human APP669-711 sequence was expressed in E. coli, with N15 as the nitrogen source.
- Purity: >97% by Mass Spec.
- Molecular Mass: 4,742 Da theoretical
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References
1. Dawkins, et al., (2014) J Neurochem., 129 (5) : 756-769
2. Nakamura, et al., (2018) Nature, 554 (7691) : 249-254
