N15 APP 669-711, Uniformly Labeled
Amyloid precursor protein (APP) is a membrane spanning protein that functions as the precursor to amyloid beta in plaques of Alzheimer’s disease patients. There are three major isoforms which have 695, 751, and 770 amino acids. The protein has a role in neuronal stem cell development, neuronal survival, neutrite outgrowth, and neurorepair 1. Recently, APP669-711 was shown to serve as a blood-based biomarker 2. This product has been uniformly labeled with N15.
$800.00 – $1,500.00
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Product Details
- Physical State: White lyophilized powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Source: Recombinant. A DNA sequence encoding the human APP669-711 sequence was expressed in E. coli, with N15 as the nitrogen source.
- Purity: >97% by Mass Spec.
- Molecular Mass: 4,742 Da theoretical
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References
1. Dawkins, et al., (2014) J Neurochem., 129 (5) : 756-769
2. Nakamura, et al., (2018) Nature, 554 (7691) : 249-254
