Nafamostat Mesylate
A potent and reversible serine protease inhibitor (IC50=0.3-54 uM). Selectively inhibits human tryptase (Ki = 95.3 pM) when employed at low concentrations. Dramatically suppresses pulmonary dysfunction in a rat model and inhibits airway eosinophilic inflammation. Anticoagulant, thrombin inhibitor which attenuates neuronal damage in a transient focal cerebral ischemia model. Also blocks TRPM7 in the absence of extracellular divalent cations. Cell permeable.
$95.00 – $270.00
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Product Details
- Physical State: White powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Molecular Mass: 539.6
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References
1. Fujii, S., and Hitomi, Y., (1981) Biochim. Biophys. Acta, 661 : 342
2. Mori, S., et al., (2003) J. Pharmacol. Sci., 92 : 420
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4. Ishizaki, M., et al., (2008) J. Pharmacol. Sci., 108 : 355
5. Chen, T., et al., (2014) Sci. Rep., 4 : 5531
6. Chen, X., et al., (2010) Mol. Brain, 3 : 38
