NE-100
NE-100 is potent inhibitor of the sigma receptor (σ) with selectivity for sigma-1 (IC50=1.5 nM) over sigma-2 (IC50=85 nM). NE-100 suppressed ischemia-induced neuronal cell death in mice via upregulation of GRP78 through the ATF6 pathway resulting in suppression of ER stress-induced cell death in a sigma-1-independent manner.
$133.00 – $428.00
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Product Details
- Physical State: White powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Molecular Mass: 391.9
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References
1. Okuyama, S., et al., (1994) Life Sci., 53 : PL285
2. Chaki, S., et al., (1994) Eur. J. Pharmacol., 251 : R1
3. Ono, Y., et al., (2013) Biochem. Biophys. Res. Commun., 434 : 904
