SB-225022

Potent and selective CXCR2 receptor antagonist (IC50 = 22 nM). Displays >150-fold selectivity over CXCR1 receptors 1. Induces apoptosis in both wild-type and p53-deficient ovarian cancer cells (OVCA) via p53 activation and by inducing mitotic catastrophe 2. Blocks IL-8-mediated cellular effects such as oxidative stress-induced cellular senescence 3 and neutrophil chemotaxis 1. Inhibits HIV replication in lymphocytes and macrophages 4. Inhibits endothelial activation and leukocyte recruitment to cerebral microvessels during neuroinflammation 5.

Catalog ID: N-3016

$114.00 – $456.00

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  • Product Details
    • Physical State: Yellow powder
    • Temperature Storage: -20°C
    • Temperature Shipping: Ambient
    • Molecular Mass: 352.14

  • References

    1. White, J.R., et al., (1998) J. Biol. Chem., 273 : 10095
    2. Du, M., et al., (2013) PLoS One, 8(1) : e54572
    3. Shen, X.H., et al., (2013) Int. Immunopharmacol., 16 : 261
    4. Lane, B.R., et al., (2001) J. Virol., 75 : 8195
    5. Wu, F., et al., (2015) J. Neuroinflammation, 12 : 98

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