Tau-441
Product background: The Tau proteins are a family of neuronal microtubule associated proteins that are found in the neurofibrillary tangles often associated with Alzheimer’s Disease. Tau promotes the assembly and maintains the structure of microtubules in neuronal cells.
About the product: Tau-441 is the mature human Tau isoform with 441 amino acids and a mass of 46kDa. Expressed recombinantly in E. coli, Tau-441 is purified to our highest standards to ensure batch to batch consistency in both purity and quality.
Applications: rPeptide Tau products can be used for a wide variety of applications including aggregation studies, assay development, fibrillization, and as standards in customer analyses.
$225.00 – $375.00
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Product Details
- Physical State: White lyophilized powder
- Temperature Storage: -20°C
- Temperature Shipping: Ambient
- Sequence:
MAEPRQEFEV MEDHAGTYGL GDRKDQGGYT MHQDQEGDTD AGLKESPLQT PTEDGSEEPG SETSDAKSTP TAEDVTAPLV DEGAPGKQAA AQPHTEIPEG TTAEEAGIGD TPSLEDEAAG HVTQARMVSK SKDGTGSDDK KAKGADGKTK IATPRGAAPP GQKGQANATR IPAKTPPAPK TPPSSGEPPK SGDRSGYSSP GSPGTPGSRS RTPSLPTPPT REPKKVAVVR TPPKSPSSAK SRLQTAPVPM PDLKNVKSKI GSTENLKHQP GGGKVQIINK KLDLSNVQSK CGSKDNIKHV PGGGSVQIVY KPVDLSKVTS KCGSLGNIHH KPGGGQVEVK SEKLDFKDRV QSKIGSLDNI THVPGGGNKK IETHKLTFRE NAKAKTDHGA EIVYKSPVVS GDTSPRHLSN VSSTGSIDMV DSPQLATLAD EVSASLAKQG L
- Source: Recombinant. A DNA sequence encoding the human tau-441 (2N4R isoform) sequence was expressed in E. coli. No his-tag.
- Purity: >90% by SDS-PAGE
- Molecular Mass: 45,900 Da theoretical
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References
1. Avila, J., et al., (2004) Physiol Rev., 84 : 361
2. Goedert, M., (1993) Trends Neurosci., 16 : 460
3. Mandelkow, E., et al., (1996) Ann N Y Acad Sci., 777 : 96
4. Goedert, M., et al., (1989) Neuron., 3 : 519
5. Himmler, et al., (1989) Mol Cell Biol., 9 : 1381
6. Tai, C., et al., (2020) Neuron., 106(3) : 421-437.e11
7. Nobuhara, C., et al., (2017) Am J Pathol., 187(6) : 1399–1412 -
Publications
Tau Is Truncated in Five Regions of the Normal Adult Human Brain
Molecular Sciences; https://doi.org/10.3390/ijms22073521
TDP-43–specific Autoantibody Decline in Patients With Amyotrophic Lateral Sclerosis
Neuroimmunology & Neuroinflammation; https://doi.org/10.1212/NXI.0000000000000937
Acta Neuropathologica Communications; https://doi.org/10.1186/s40478-020-01117-y
Plexin-A4 mediates amyloid-β–induced tau pathology in Alzheimer’s disease animal model
ScienceDirect; https://doi.org/10.1016/j.pneurobio.2021.102075
Mural cell dysfunction leads to altered cerebrovascular tau uptake following repetitive head trauma
ScienceDirect; https://doi.org/10.1016/j.nbd.2020.105237
Molecular Degeneration(2023) 18 (1), 29 DOI: 10.1186/s13024-023-00621-8
Brain-derived tau: a novel blood-based biomarker for Alzheimer’s disease-type neurodegeneration
Brain (2023) 146 (3), 1152-1165 DOI: 10.1093/brain/awac407
Single-domain antibody–based noninvasive in vivo imaging of α-synuclein or tau pathology
Science Advances (2023) 9 (19), eadf3775 DOI: 10.1126/sciadv.adf3775
Cell & Bioscience (2023) 13 (1), 174 DOI: 10.1186/s13578-023-01133-0
Cell Reports (2023) 42 (12), 113529 DOI: 10.1016/j.celrep.2023.113529
